Assoc. Prof. Dr. BURÇİN ÇAKAN DEMİREL

Medical Oncology

Medipol Mega University Hospital
BURÇİN ÇAKAN DEMİREL

Birthplace

EDİRNE

Languages

ENGLISH

Medical Areas of Interest

  • Breast Cancer
  • Gastrointestinal System Cancers
  • Lung Cancer
  • Gynecological Cancers
  • Genitourinary System Cancers
  • Immunotherapy and Targeted Therapies
  • Personalized Cancer Treatments

Highlights

Asst. Prof. Burçin Çakan Demirel, MD was born in Edirne in 1989. She completed her medical education at Adnan Menderes University Faculty of Medicine in 2013.

She completed her Internal Medicine residency at the Department of Internal Medicine, Istanbul Medipol University Faculty of Medicine, and became an Internal Medicine Specialist in 2018. Her specialty thesis was on clinicopathological factors and their effects on prognosis in patients with metastatic colorectal cancer.

After her Internal Medicine specialty, she fulfilled her state service obligation in 2019 at Amasya Taşova State Hospital and Elazığ Fethi Sekin City Hospital.

She completed her Medical Oncology subspecialty training at the Division of Medical Oncology, Pamukkale University Faculty of Medicine, and became a Medical Oncology Specialist in 2023.

After her Medical Oncology specialty, she fulfilled her state service obligation at Bağcılar Training and Research Hospital from 2023 until July 2025.

She started working at Istanbul Medipol University in July 2025; as of January 2026, she continues her academic and clinical work as an Assistant Professor at the Department of Internal Medicine, Istanbul Medipol University Faculty of Medicine.

She is a member of various national and international scientific societies in the field of oncology, notably the Turkish Society of Medical Oncology and the European Society for Medical Oncology (ESMO).

In her scientific work, she conducts studies on systemic treatments of various solid tumors, evaluation of treatment response and prognostic factors. Breast cancer holds an important place among her clinical and academic interests, and she has various scientific studies in this field.

She has 40 scientific articles published in national and international peer-reviewed scientific journals, as well as oral and poster presentations at national and international scientific meetings.

Reflecting current scientific developments in her clinical practice, Dr. Çakan Demirel adopts personalized treatment approaches in cancer therapy by evaluating tumor biology, disease characteristics and patient-related factors together.

Experiences

2023 - 2025

Bağcılar Training and Research Hospital

M.D., Specialist

2019 - 2019

Amasya Taşova State Hospital

M.D., Specialist

2019 - 2019

Elazığ Fethi Sekin City Hospital

M.D., Specialist

Educations

2023

Pamukkale University Faculty of Medicine, Medical Oncology

2018

Istanbul Medipol University Faculty of Medicine, Internal Medicine

2013

Adnan Menderes University, Faculty of Medicine

Publications

7.1. Articles published in internationally refereed journals (SCI & SSCI & Arts and Humanities)

Çakan B, Açikgöz O, Bilici A, Demir T, Oven BB, Hamdard J, Olmuşçelik O, Ölmez OF, Şeker M, Yıldız Ö. Prognostic significance of primary tumor localization in patients with metastatic colorectal cancer: Is it beneficial to select targeted treatment? Real-life experience from Turkey. JBUON. 2021;26(5):1908-1917.

Goktas Aydin S, Cakan Demirel B, Bilici A, et al. Real-life analysis of treatment approaches and the role of inflammatory markers on survival in patients with advanced biliary tract cancer. Curr Med Res Opin. 2022;38(10):1751-1758. doi:10.1080/03007995.2022.2108619

Demiray AG, Yaren A, Sungurtekin U, Baltalarli PB, Demirkan N, Herek D, Yapar Taskoylu B, Gokoz Dogu G, Degirmencioglu S, Ozgen U, Saginc H, Cakiroglu U, Ozhan N, Karan C, Cakan Demirel B, Dogan T, Ozdemir M. The effect of continuing chemotherapy after chemoradiotherapy during the time to surgery on tumor response and survival for local advanced rectal cancer. J Oncol. 2022;2022:4108677. doi:10.1155/2022/4108677

Acikgoz O, Cakan B, Demir T, et al. Platelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer. Medicine (Baltimore). 2021;100(44):e27712. doi:10.1097/MD.0000000000027712

Demiray AG, Demiray A, Yaren A, Yapar Taskoylu B, Gokoz Dogu G, Degirmencioglu S, Cakiroglu U, Ozhan N, Karan C, Cakan Demirel B, Dogan T, Ozdemir M. Evaluation of serum microRNA Let-7c and Let-7d as predictive biomarkers for metastatic pancreatic cancer. Turk J Gastroenterol. 2022;33(3):257–263. doi:10.5152/tjg.2022.21829

Karacin C, Oksuzoglu B, Demirci A, Keskinkilic M, Kose Baytemur N, Yilmaz F, Selvi O, Erdem D, Avsar E, Paksoy N, Demir N, Sezgin Goksu S, Turker S, Bayram E, Celebi A, Yilmaz H, Kuzu OF, Kahraman S, Gokmen I, Sakin A, Alkan A, Nayir E, Ugrakli M, Acar O, Erturk I, Demir H, Aslan F, Sonmez O, Korkmaz T, Celayir OM, Karadag I, Kayikcioglu E, Sakalar T, Oktem IN, Erenc T, Erul E, Eylemer Mocan E, Kalkan Z, Yildirim N, Ergun Y, Akagunduz B, Karakaya S, Kut E, Teker F, Cakan Demirel B,et al. Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK4/6 inhibitor therapy. BMC Cancer. 2023;23(1):1261. doi:10.1186/s12885-023-11564-5

Karan C, Yaren A, Demirel BC, et al. Pretreatment PLR is preferable to NLR and LMR as a predictor in locally advanced and metastatic bladder cancer. Cancer Diagn Progn. 2023;3(6):706-715. doi:10.21873/cdp.10275

Kınıkoğlu O, Odabaş H, Altıntaş YE, Yıldız A, Çakan B, Akdağ G, Yıldırım S, Bal H, Kaya T, Tünbekici S, et al. Combining endocrine therapy with trastuzumab emtansine improves progression-free survival and overall survival in HER2-positive, hormone receptor-positive metastatic breast cancer. Medicina. 2024;60(6):951. doi:10.3390/medicina60060951

Kahraman S, Erul E, Gumusay O, Guven DC, Aksoy S, Basaran G, Seyyar M, Sahin E, Cabuk D, Bayram E, Paydas S, Cakan Demirel B, et al. Real-world treatment efficacy of ribociclib or palbociclib plus fulvestrant in hormone receptor-positive/HER2-negative metastatic breast cancer: Turkish Oncology Group (TOG) study. BMC Cancer. 2024;24(1):726. doi:10.1186/s12885-024-12347-3

Kahraman S, Erul E, Gumusay O, Guven DC, Aksoy S, Basaran G, Yaren A, Cakan Demirel B, et al. Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age subgroups: Turkish Oncology Group (TOG) retrospective study. BMC Cancer. 2024;24(1):1275. doi:10.1186/s12885-024-12775-0

7.3. Papers presented at international scientific meetings and published in proceedings

Goktas Aydin S, Aydin A, Cakan Demirel B, Demir O, Bayramgil A, Kutlu O, Yildirim C, Aksoy A, Gulturk I, Taskaynatan H, Senocak Tasci E, Koseoglu C. A multi-center case-control study on osteoporosis risk in cancer patients receiving chemotherapy. J Clin Oncol. 2025;43(16_suppl):12033. doi:10.1200/JCO.2025.43.16_suppl.12033

Effect of the CONUT Score on Survival in Metastatic Hormone-Positive HER2-Negative Breast Cancer Patients Receiving a CDK4/6 Inhibitor, AMORE-2022

Effect of Pretreatment Absolute Lymphocyte, Albumin, Hemoglobin, C-Reactive Protein and LDH Levels on Survival in Patients with Metastatic Biliary Tract and Gallbladder Cancer: A Single-Center Experience - TTOK 2022

7.4. International books written or book chapters

7.5. Articles published in national refereed journals and papers published in proceedings

Yapar Taşköylü B, Avcı E, Demiray AG, Değirmencioğlu S, Gököz Doğu G, Yaren A, Ergin A, Kılıç D, Karan C, Çakan Demirel B, Doğan T, Özdemir M. Relationship between neutrophil/lymphocyte, platelet/lymphocyte, CRP/albumin ratio and survival in ovarian cancer. Pamukkale Medical Journal. 2021;14(3):763-769. doi:10.31362/patd.907695

Demiray AG, Yaren A, Yapar Taskoylu B, Degirmencioglu S, Gokoz Dogu G, Cakiroglu U, Ozhan N, Karan C, Cakan Demirel B, Dogan T, Ozdemir M. Should vitamin D level be measured before denosumab in patients with castration-resistant metastatic prostate cancer to prevent hypocalcemia? EJMI. 2021;5(3):313–316. doi:10.14744/ejmi.2021.48218

Göktaş Aydın S, Çakan Demirel B, Bilici A, Yılmaz C, Topçu A, Aykan MB, Kahraman S, Atcı MM, Akbıyık I, Akgül F, Ölmez ÖF, Aydın A. The optimal treatment approaches and prognostic factors in elderly patients with advanced stage biliary tract tumors. Acta Oncologica Turcica. 2023;56:81-89. doi:10.5505/aot.2023.03708

Yapar Taskoylu B, Gokoz Dogu G, Cakan Demirel B, Sari T, Demiray AG, Degirmencioglu S, Yaren A, Ergin A, Avci E, Karan C, Dogan T, Ozdemir M. Evaluation of clinical, laboratory and treatment findings of oncology patients diagnosed with COVID-19 infection. EJMI. 2021;5(4):417–421. doi:10.14744/ejmi.2021.27607

Cakan Demirel B, Yaren A, Demiray AG, Yapar Taşköylü B, Doğan T, Özdemir M, Güçlü Kantar T, Karan C, Değirmencioğlu S, Gököz Doğu G. Prognostic significance of systemic immune inflammation indices and prognostic nutritional index before CDK4/6 inhibitor therapy in hormone receptor–positive, HER2–negative metastatic breast cancer patients. Pamukkale Med J. 2023;16(4):682-695. doi:10.31362/patd.1268419

Ozdemir M, Gokoz Dogu G, Yapar Taskoylu B, Demiray AG, Degirmencioglu S, Yaren A, Cakan Demirel B, Dogan T, Guclu Kantar T, Tas S, Acikgoz Yildiz B, Serin Ozel G, Mordag Cicek C. Prognostic value of a new marker, IBI score and NLR change in non-small cell lung cancer patients receiving immune checkpoint inhibitors (Prognostic value of IBI score and NLR change in NSCLC). Med J Mugla Sitki Kocman Univ. 2025;12(2):91-98. doi:10.47572/muskutd.1603917

Yapar Taskoylu B, Bir F, Demiray AG, Degirmencioglu S, Gokoz Dogu G, Yaren A, Ergin A, Karan C, Cakan Demirel B, Dogan T, Ozdemir M, Guclu Kantar T. The association of mismatch-repair (MMR) deficiency with tumor infiltrating lymphocytes and survival in patients with ovarian cancer. EJMA. 2024;4(1):22–27. doi:10.14744/ejma.2023.74946

Dogan T, Yaren A, Demiray AG, Yapar Taskoylu B, Cakan Demirel B, Ozdemir M, Guclu Kantar T, Degirmencioglu S, Gokoz Dogu G. The effect of pre-treatment inflammatory response markers on survival in locally advanced unresectable and metastatic gastric cancer: a retrospective cross-sectional study. Pamukkale Med J. 2024;17(2):XXX–XXX. doi:10.31362/patd.1265291

Kahraman S, Hizal M, Gumusay O, Basaran G, Seyyar M, Sahin E, Cabuk D, Yasar A, Bayoglu IV, Bayram E, Paydas S, Gulbagci B, Hacibekiroglu I, Cakan Demirel B, et al. HER2-low expression in patients with hormone receptor-positive and HER2-negative advanced breast cancer treated with ribociclib or palbociclib in combination with endocrine therapy. Turk J Clin Lab. 2024;15(2):255–262. doi:10.18663/tjcl.1639022

Ozdemir M, Gokoz Dogu G, Yapar Taskoylu B, Demiray AG, Degirmencioglu S, Yaren A, Arslan M, Cakan Demirel B, Dogan T, Guclu Kantar T, Tas S, Acikgoz Yildiz B, Serin Ozel G, Mordag Cicek C. Use of albumin and CRP-related immuno-nutritional markers for prediction of locoregional response to treatment in unresectable hepatocellular carcinoma. Pamukkale Med J. 2025;18(1):87–97. doi:10.31362/patd.1471860

Ozdemir M, Gokoz Dogu G, Yapar Taskoylu B, Yaren A, Degirmencioglu S, Demiray AG, Erdemir A, Cakan Demirel B, Dogan T, Guclu Kantar T, Tas S, Acikgoz Yildiz B, Serin Ozel G, Mordag Cicek C. The impact of SARS-CoV-2 infection on the survival in NSCLC patients undergoing immunotherapy. Pamukkale Med J. 2025;18(4):733–747. doi:10.31362/patd.1598359

7.7. Other publications

Cakan Demirel B. Empirical antibiotic therapy in febrile cancer patients. In: Soylu HM, Sedef AM, eds. Cancer and Infection. Ankara: Akademisyen Kitabevi; 2023:117–126. doi:10.37609/akya.2853. ISBN 9786253994051.

Cakan Demirel B. Atrial fibrillation in cancer patients. In: Baysal E, Okşul M, Şener YZ, eds. Current Approach to the Diagnosis and Treatment of Atrial Fibrillation. Ankara: Akademisyen Kitabevi; 2023:197–206.

Cakan Demirel B. Cancer treatment-related hypertension and its management. In: Dilmen Y, ed. Current Approach to the Diagnosis and Treatment of Hypertension. Ankara: Akademisyen Kitabevi; 2023:311–321. doi:10.37609/akya.607. ISBN 9786257496025.