Prof. Dr. MUSTAFA KÜRŞAT ÖZVARAN

Articles Published in International Peer-Reviewed Journals

1. Baran, R., M. Tor, K. Tahaoğlu, K. ÖZVARAN, A. Kır, Ö. Kızgın, H. Türker. "Intrathoracic Tuberculous Lymphadenopathy: Clinical and Bronchoscopic Features in 17 Adults Without Parenchymal Lesions". Thorax, 51,87-89 (1996). 2. Baran, R., A. Kır, M. Tor, K. ÖZVARAN, A. Tunacı. "Scimitar Syndrome: Confirmation of Diagnosis by a Noninvasive Technique (MRI)". European Radiology, 6, 92-94 (1996). 3. Tor, M., K. ÖZVARAN, Y. Ersoy, T. Şenol, N. Altuntaş, G. Kılıçoğlu, L. Çelik. "The Pitfalls in the Diagnosis of Compicated Pulmonary Hydatid Disease". Respiratory Medicine, 95, 121-7 (2001). 4. Karahalli, E, A. Yılmaz, H. Türker, K. OZVARAN. "Usefulness of Various Diagnostic Techniques During Fiberoptic Bronchoscopy for Endoscopically Visible Lung Cancer: Should Cytologic Examinations be Performed Routinely?" Respiration, 68,611-614 (2001). 5. Mohiuddin, I., X. Cao, M. K. OZVARAN, L. Zumstein, S. Chada, R. Smythe. "Phosphatase and Tensin Analog Gene Overexpression Engenders Cellular Death in Human Malignant Mesothelioma Cells via Inhibition of AKT Phosphorylation". Annals of Surgical Oncology, 9,310-316 (2002). 6. Smythe, R., I. Mohuiddin, M.K.ÖZVARAN, X. Cao. "Antisense Therapy for Malignant Mesothelioma with Oligonucleotides Targeting the bcl-xl Gene Product". The Journal of Thoracic and Cardiovascular Surgery, 123,1191-8 (2002). 7. Cao, X., I. Mohuiddin, S. Mhashilkar, M. K. OZVARAN, D. McConkey, S. Miller, J. Daniel, R. Smythe. "Adenoviral Transfer of mda-7 Leads to BAX Up-regulation and Apoptosis in Mesothelioma Cells, and is Abrogated by Over-expression of BCL-XL". Molecular Medicine, 8, 869-876 (2002). 8. OZVARAN, M.K., Y. Ersoy, B. Üskül, E. Ünver, E. Yalçın, R. Baran, R. C. Morice. "Pleural Complications of Pulmonary Hydatid Disease". Respirology, 9,115-119 (2004). 9. OZVARAN, M.K., X. X. Cao, S. D. Miller, B. A. Monia, W. K. Hong, and W. R. Smythe. "Antisense oligonucleotides directed at the bcl-xl gene product augment chemotherapy response in mesothelioma". Mol Cancer Ther, 3,545–50 (2004). 10. Miller, SD, I. Mohiuddin, X.X. Cao, M.K. OZVARAN, J.C. Daniel, W.R. Smythe. "Gene therapy for sarcoma utilizing adenoviral transfer of the beta-glucuronidase and bax genes and an anthracycline prodrug". J Surg Res, 121,153-8 (2004). 11. OZVARAN, M.K., R. Baran, O. Soğukpınar, K. Sahin, O. Uzman, F. Aksoy, S. Altun. "Histopathologic diagnosis of endobronchial endometriosis treated with argon plasma". Respirology,11,348-350, (2005). 12. ÖZVARAN M.K, Baran R, Tor M, Dilek İ, Demiryontar D, Arınç S, Toker N, Chousein E.U, Soğukpınar Ö. Extrapulmonary tuberculosis in non-human immunodeficiency virus infected adults in an endemic region: A review of 2,435 patients. Annals of Thoracic Medicine,2,118-121 (2007). 13. Littlejohn J.E, Cao X, Miller S.D, OZVARAN M.K, Jupiter D, Zhang L, Rodarte C, Smythe W.R. Bcl-xL antisense oligonucleotide and cisplatin combination therapy extends survival in SCID mice with established mesothelioma xenografts. Int.J.Cancer,123,202-208 (2008). 14. Baysungur V, Tezel Ç, Okur E, Ergen G, ÖZVARAN K, Halezeroğlu S. An unusual presentation of Castleman's disease. Respirology,15, 1009-1014 (2010).

Papers Presented at International Scientific Meetings and Published in Proceedings

1. Baran, R, F. Ü. Ertan, K. ÖZVARAN, G. Dolunay. "Primary Drug Resistant Tuberculosis in Children: A Report From Turkey". Tubercle and Lung Disease, 28th World Conference of IUATLD/UICTMR Mainz, Germany, Vol 75, Supp 1, Churchill Livingstone, 1-158,1994. 2. Tor, M., R. Baran, İ. Dilek, F. Aksoy, S. Unutmaz, K. ÖZVARAN. "Pitfalls In The Diagnosis of Tuberculosis". European Respiratory Journal Annual Congress, Madrid, Vol 14, supp 30, The Society and Munksgaard, Copenhagen,1999. 3. Smythe, R., X. Cao, I. Mohuiddin, M. K. OZVARAN. "Augmentation of Pro-Apoptotic Gene Therapy and Conventional Chemotherapy via Pharmacologic Down-Regulation of bcl-XL Expression". Texas Medical Center Gene Therapy Symposium 2001. 4. Cao, X., M. K. OZVARAN, S. Miller, R. Smythe. "A bcl-xl Antisense Adenoviral Vector: A Novel and Effective Pro-Apoptotic Gene Therapy Construct". The Fifth Annual Meeting of The American Society of Gene Therapy, Houston, Molecular Therapy, Vol 5, Nu 5, S 68, Elsevier, 2002. 5. Miller, S., X. Cao, M. K. OZVARAN, R. Smythe. "PI3 Kinase Inhibition Overcomes Resistance to Apoptosis in Mesothelioma via BCL-XL-Independent Inhibition of NF-Kb". The Association for Academic Surgery, Thirty Sixth Annual Meeting, Boston, Massachusetts, 2002. 6. Cao, X., J. Gu, S. Miller, M. K. OZVARAN, R. Smythe. "Histone Deacetylase Inhibitor Enhancement of Adenoviral Transgene Expression In Tumor Cell Lines: Mechanism and Therapeutic Potential". 06-10 April 2002, 93rd Annual American Association for Cancer Research Meeting, San Francisco, California, Vol 43, 2002. 7. OZVARAN M.K., X. Cao, S. Miller, K. Kim, R. Smythe. "Histone Deacetylase Inhibition Augments Human Mesothelioma Cellular Response to Chemotherapy". 17-22 May 2002, 97th American Thoracic Society International Conference, Atlanta, Georgia, American Journal of Respiratory and Critical Care Medicine Volume 165, Number 8, April 2002. 8. OZVARAN M.K., X. Cao, S. Miller, B. Monia, R. Smythe. "Antisense Oligonucleotides Directed at the Bcl-X Gene Product Significantly Augment Chemotherapy Response in Mesothelioma". 5-08 May 2002, The American Association for Thoracic Surgery 82nd Annual Meeting, Washington, DC, 2002. 9. Miller, S., X. Cao, M. K. OZVARAN, J. Daniel, R. Smythe. "PI3 Kinase Inhibition of Akt Phosphorylation in Mesothelioma Induces Apoptosis in Vitro and Significantly Reduces Tumor Burden in Vivo". 12-15 February 2003, Society of University Surgeons, 64th Annual Meeting, University of Texas Health Science Center at Houston Medical School, Houston, Tx, 2003. 10. Cao, X, J. Daniel, M. K. OZVARAN, S. Miller, R. Smythe. "SiRNA Vectors Targeted to BCL-XL Significantly Reduce BCL-XL Expression and Enhance Response to Chemotherapy in Non-Small Cell Lung Adenocarcinoma". 04-08 June 2003, Abstracts from the 6th Annual Meeting of the American Society of Gene Therapy, Molecular Therapy, The Journal of the American Society of Gene Therapy, Volume 7, Number 5, S 289, May 2003. 11. Cao, X., S. Miller, M. K. OZVARAN, J. Daniel, R. Smythe. "A Short-Interfering RNA (siRNA) Duplex targeted to BCL-XL Significantly Reduces BCL-XL Expression and Enhances Response to Chemotherapy in Mesothelioma". 05-09 April 2003, American Association for Cancer Research 94th Annual Meeting, Toronto, Ontario, Canada, Volume 44, S 1264, 2003. 12. OZVARAN, M.K., S. Miller, X. Cao, K. Kim, R. Smythe. "Adenoviral-Mediated PTEN Overexpression Enhances Response to Chemotherapy in Mesothelioma via Reduction in AKT Phosphorylation and Down-Regulation of BCL-XL Protein Levels". 16-21 May 2003, 98th American Thoracic Society International Conference, Seattle, Washington, American Journal of Respiratory and Critical Care Medicine, Volume 167, Number 7, S A900, April 2003. 13. OZVARAN, M.K., Y. Ersoy, B. Üskül, E. Ünver, E. Yalçın, R. Baran, R. Morice. "Pleural Complications of Pulmonary Hydatid Disease". 16-21 May 2003, 98th American Thoracic Society International Conference, Seattle, Washington, American Journal of Respiratory and Critical Care Medicine, Volume 167, Number 7, April 2003. 14. Ersoy, Y.M., M.K. OZVARAN, L. Keus, C. Y. Alisonorin, C. A. Jimenez, R. C. Morice. "Usefulness of Chest X-Ray Planimetry For Predicting Postoperative Pulmonary Function For Patients Undergoing Lung Resection". Annual Meeting of The American College of Chest Physicians, San Diego-CA 2003. 15. Daniel, J.C., X. Cao, S. D. Miller, N. G. Ordonez, P. Rascoe, M. K. OZVARAN, W. R. Smythe. "Expression of Constitutively Active Akt in Human Mesothelioma Specimens and the Role of Specific Akt Isoforms In Vitro". Proc. The Annual Meeting of American Association for Cancer Research, Volume 45, Number 3528, 2004. 16. Cao, X., J. C. Daniel, S. D. Miller, P. Rascoe, M. K. OZVARAN, W. R. Smythe. "Histone Deacetylase Inhibitors Can Enhance Adenovirus Mediated Gene Expression". Proc. The Annual Meeting of American Association for Cancer Research, Volume 45, Number 2340, 2004. 17. OZVARAN, M.K., J. C. Daniel, X. Cao, P. Rascoe, W. R. Smythe. "Antisense Induced Bcl-xl Downregulation is Countered by Bcl-2 Upregulation in Mesothelioma – Does this Phenomenon Contribute to Chemotherapeutic Resistance?". Proc. 100th ATS International Conference May 20-25; vol 2: San Diego, CA, 2005. 18. OZVARAN, M.K., İ. Dilek, D. Demiryontar, S. Arınç, N. Toker, E. U. Chousein, Ö. Soğukpınar, T. Karagöz, R. Baran. "Evaluation of Extra-pulmonary Tuberculosis in the Last Five Years". Proc. 100th ATS International Conference May 20-25; vol 2: San Diego, CA, 2005.

Articles Published in National Peer-Reviewed Journals

1. Baran, R., M. Tor, F. Ü. Ertan, K. ÖZVARAN, F. Aksoy, N. Başözdemir. "Evaluation of Secondary Lung Malignancies Developing in 10 Cases Operated for Primary Laryngeal Cancer." Solunum Congress Book, vol 19, 482-487, (1994). 2. Baran, R., F. Aksoy, F. Ü. Ertan, K. ÖZVARAN. "Pulmonary Alveolar Proteinosis: Diagnosis by Sputum Examination and Segmental Lavage." Solunum Congress Book, vol 19,688-692,(1994). 3. Baran, R, F. Kebanlı, F. Ü. Ertan, K. ÖZVARAN, A. Yılmaz. "Immunoglobulin and Immunoglobulin G Subgroup Levels in Patients with Bronchiectasis". Tüberküloz ve Göğüs Hastalıkları, XLI 41-47, (1993). 4. Tor, M., R. Baran, F. Ü. Ertan, K. ÖZVARAN. "A Case of Neurofibromatosis with Pulmonary Involvement". Heybeliada Medical Bulletin, 1,81-85 (1995). 5. ÖZVARAN, M.K., E. Ünver, T. B. Üskül, Y. Ersoy, İ. Dilek, E. Yalçın, S. Düzgün, R. Baran. "An Evaluation of Diagnosis and Treatment of Pulmonary Hydatid Cyst in Patients Over 50 Years Old". Turkish Respiratory Journal, 1, 11-13 (2000). 6. ÖZVARAN, K., A. Yılmaz, M. Ertuğrul, E. Yalçın, R. Baran. "Evaluation of Surgical Treatment in Aspergilloma". Solunum, 3, 306-309 (2001). 7. ÖZVARAN, M.K., M. Ertuğrul, B. Üskül, M. Tor, S. Düzgün, R. Baran. "Evaluation of Clinical, Radiological and Predisposing Factors in Pulmonary Embolism". Göztepe Medical Journal, 15, 93-95 (2000). 8. Düzgün, S, B. Üskül, K. ÖZVARAN, N. Altuntaş, R. Baran, İ. Rozanes. "Bronchial Artery Embolization in the Treatment of Hemoptysis". Solunum, 2, 52-55 (2000). 9. ÖZVARAN K, A. Yılmaz, Y. Ersoy, B. Üskül, H. K. Okur, E. Ünver, S. Düzgün, E. Yalçın, R. Baran. The Role of Open Lung Biopsy in the Diagnosis of Diffuse Interstitial Lung Disease. Turkish Respiratory Journal, 2, 28-31 (2001). 10. Yılmaz, A., K. ÖZVARAN, S. Unutmaz, B. Bayramgürler, E. Akkaya, Ö. Yazıcıoğlu, S. Düzgün. Is the Distribution of Tumor Type and Certain Epidemiological Characteristics Changing in Lung Cancer Cases? (1992-1998). Toraks Dergisi, 2, 6-8 (2001). 11. ÖZVARAN, K, B. Üskül, Y. Ersoy, S. Düzgün, N. Altuntaş, H. Ergin. "Diagnosis of Intralobar Sequestration by Magnetic Resonance Angiography". Solunum, 4, 34-37 (2002). 12. ÖZVARAN M.K. Gene therapy in malignant mesothelioma. Toraks Dergisi,5,110-5 (2004). 13. ÖZVARAN M.K., H. Okur, M. Özgel, M. Ertuğrul, R. Baran. "Diagnostic value of adenosine deaminase and its isoenzymes in tuberculous pleurisy". Toraks Dergisi,5,166-70, (2004). 14. Ertuğrul, M., Z. Karakurt, N. Güngör, E. Sulu, M. K. ÖZVARAN, M. Özgel, H. Türker. "Contribution of latex method D-dimer blood levels to the diagnosis of pulmonary thromboembolism". Göztepe Medical Journal,19,193-195, (2004). 15. Hurşitoğlu, M., E. U. Chousein, M. K. ÖZVARAN. "HIV and pulmonary complications". SSK Vakıf Gureba Training Hospital Journal, 2, 14-21, (2004). 16. ÖZVARAN M. K., M. Ertuğrul, Y. Ersoy, E. Ünver, İ. Dilek, E. Yalçın, R. Baran. "The Effect of Decortication on Lung Function in Chronic Tuberculous and Nonspecific Empyema". Solunum,7,18-22, (2004). 17. ÖZVARAN M. K., H. K. Okur, M. Özgel. "Tuberculous Pleurisy and Adenosine Deaminase". Selçuk Medical Journal, 20,123-127, (2004). 18. ÖZVARAN M. K., S. Arınç, Ö. Uzman, İ. Dilek, E. U. Chousein, D. Demiryontar, R. Baran. "Evaluation of Lung Lesions That Could Not Be Diagnosed by CT-Guided Transthoracic Needle Aspiration". İnönü University Faculty of Medicine Journal,12,231-234, (2005). 19. Arınç, S., B. Arınç, M. K. ÖZVARAN, Ö. Uzman, R. Baran. "Evaluation of Elderly and Young Cases with Pulmonary Tuberculosis". Solunum Hastalıkları Dergisi,16,119-126, (2005). 20. ÖZVARAN M. K., D. Demiryontar, S. Arınç, F. Abacıgil, E. U. Chousein, Ö. Soğukpınar, N. Toker, R. Baran. "Evaluation of Brain Metastases in Lung Cancer Patients". İnönü University Faculty of Medicine Journal,12,89-92,(2005). 21. ÖZVARAN M. K., E. G. U. Chousein, İ. Dilek, D. Demiryontar, M. Özgel, K. Tahaoğlu, R. Baran. "Evaluation of Uric Acid Levels in Tuberculosis Patients". Solunum Hastalıkları Dergisi (in press). 22. ÖZVARAN M. K., S. Arınç, Ö. Soğukpınar, N. Toker, E. U. Chousein, R. Baran. "Evaluation of Intrathoracic Neurogenic Tumors in Adults". Selçuk Medical Journal, 21,72-74,(2005). 23. ÖZVARAN, M. K., S. Arınç, N. Güngör, Ö. Soğukpınar, N. Toker, R. Baran. "Evaluation of Patients with Bronchoalveolar Carcinoma". Okmeydanı Hospital Medical Journal, 22,23-26,(2005). 24. Chousein, E. G. U., M. K. ÖZVARAN, M. Ş. Yüceege, M. Hurşitoğlu, R. Baran. "Recurrent Pulmonary Infections Due to Congenital Epiglottic Hypoplasia." SSK Vakıf Gureba Training Hospital Journal, 3,45-47,(2005). 25. Arınç S., ÖZVARAN M. K., N. Güngör, Çelik O., Ö. Soğukpınar, Çollak F., R. Baran. Epidemiological and Histological Characteristics of Lung Cancer Cases Diagnosed at Our Hospital. Akciğer Arşivi,6.149-152,(2005). 26. ÖZVARAN M.K. New Treatments in Malignant Mesothelioma. Dispne,2,121-125, (2007). 27. OZVARAN M.K. New treatment methods. TTD Pleura Bulletin 2009, 3:1; p 31-36.

Papers Presented at National Scientific Meetings and Published in Proceedings

1. Baran, R., M. Tor, K. ÖZVARAN, K. Tahaoğlu, D. Güder, A. Kır. "The Role of Bronchoscopy in the Diagnosis of Complicated Pulmonary Hydatid Cyst Disease". 20th Anniversary Lung Days - Uludağ University Faculty of Medicine, Bursa, 1995. 2. Güder, D., R. Baran, S. Sivaslıoğlu, G. Dolunay, K. ÖZVARAN, K. Şahin. "Evaluation of Demographic, Radiological and Bacteriological Findings of 224 Pediatric Patients Treated with a Diagnosis of Pulmonary Tuberculosis". 20th Anniversary Lung Days - Uludağ University Faculty of Medicine, Bursa, 1995. 3. Kır, A., R. Baran, A. Yılmaz, B. Üskül, D. Güder, K. ÖZVARAN. "Pancoast Tumors (Evaluation of 17 Cases)". Turkish Thoracic Society 1st Annual Congress, 59, Nevşehir, 1996. 4. Tor, M., K. ÖZVARAN, T. Moralı, R. Baran, N. Hatabay. "Evaluation of Radiological Findings in 100 Consecutively Followed Fresh Tuberculosis Cases". 69, Marmaris, 1996. 5. Tor, M., R. Baran, İ. Dilek, F. Aksoy, S. Unutmaz, K. ÖZVARAN, A. Atasalihli. "Different Presentations of Tuberculosis and Diagnostic Difficulties". Turkish Thoracic Society (TÜSAD) 25th National Congress, P 108, İstanbul, 1999. 6. ÖZVARAN M. K., S. Arınç, İ. Dilek, Ö. Uzman, D. Demiryontar, E. U. Chousein, R. Baran. "Demographic Evaluation of Malignant Mesothelioma Cases over 5 Years at Our Hospital". 7th Turkish Thoracic Society Congress, 121, Antalya, 2004. 7. Arınç, S., B. Arınç, K. ÖZVARAN, Ö. Uzman, R. Baran. "Comparison of Young and Elderly Tuberculosis Cases". 7th Turkish Thoracic Society Congress, 1st Place Poster Presentation Award, 200, Antalya, 2004. 8. ÖZVARAN M.K., S. Arınç, İ. Dilek, Ö. Uzman, E. U. Chousein, D. Demiryontar, R. Baran. "Evaluation of Lung Lesions That Could Not Be Diagnosed by CT-Guided Transthoracic Needle Aspiration". 7th Turkish Thoracic Society Congress, 57, Antalya, 2004. 9. ÖZVARAN M. K., D. Demiryontar, S. Arınç, F. Abacıgil, E. U. Chousein, Ö. Soğukpınar, N. Toker, R. Baran. "Evaluation of Brain Metastases in Patients with Non-Small Cell Lung Cancer." 8th Turkish Thoracic Society Congress, Antalya 2005. 10. Arınç, S., K. ÖZVARAN, Ö. Soğukpınar, İ. Dilek, F. Çollak, F. Aksoy, L. Alpay, R. Baran, "Investigation of the Diagnostic Value of Peripheral Lymph Node Biopsies". 8th Turkish Thoracic Society Congress, Antalya 2005. 11. Arınç, S., K. ÖZVARAN, F. Çollak, İ. Dilek, Ö. Soğukpınar, F. Aksoy, L. Alpay, R. Baran. "Evaluation of Lymphoma Cases at Our Hospital". 8th Turkish Thoracic Society Congress, Antalya 2005. 12. ÖZVARAN M. K., M. Tor, İ. Dilek, D. Demiryontar, S. Arinc, N. Toker, E. U. Chousein, O. Sogukpinar, T. Karagoz, R. Baran. "Evaluation of Extrapulmonary Tuberculosis in HIV-Negative Adults in an Endemic Region: In 2435 Cases". 8th Turkish Thoracic Society Congress, Antalya 2005. 13. ÖZVARAN M. K, Baran R, Kargın F, Altınöz H, Hacıömeroğlu O, Sogukpınar Ö. Evaluation of Argon Plasma in Endobronchial Treatment in Lung Cancer. 10th Turkish Thoracic Society Congress, Antalya 2007. (Received 3rd Place Award). 14. Baran R, Altınöz H, Boğa S, Hacıömeroğlu O, ÖZVARAN M. K, Horzum G, Sogukpınar Ö. Total Lung Lavage in Primary Pulmonary Alveolar Proteinosis (Analysis of Our Cases). 11th Turkish Thoracic Society Congress, Antalya 2007. 15. OZVARAN M.K, Kuyucu T, Hazar A. 7 Patients Undergoing Endobronchial Treatment: 11 Interventions. 32nd TÜSAD Congress, Antalya 2010.

Awards

1. 7th Turkish Thoracic Society Congress, Poster Presentation (1st Place Award), Antalya, 2004 2. 10th Turkish Thoracic Society Congress (3rd Place Award), Antalya 2007